Prof Jill Trewhella

Email jtrewhella@usyd.edu.au

Professor Jill Trewhella received her BSc (Hons 1) in Physics and Applied Mathematics (1975) and MSc in Physics (1978) from the University of NSW. Her PhD (1981) is in Chemistry from the University of Sydney. She moved to the United States in 1980 to complete post doctoral studies at Yale University in the Department of Biophysics and Biochemistry, and in 1984 went to Los Alamos National Laboratory to establish a structural molecular biology program associated with the spallation neutron source there. Jill held various science leadership and management positions at Los Alamos before being named Laboratory Fellow (1995) in recognition of sustained outstanding contributions to science and technology. She has published ~100 original research papers, book chapters, pedagogical articles, and reviews on structural biology, with a focus on molecular signaling in cells and the control of enzyme activity. This work gained her the recognition of being named a Fellow of the American Association for the Advancement of Science and a 2004 Australian Federation Fellow. She is taking up her appointment as Professor of Molecular and Microbial Biosciences at the University of Sydney with a joint appointment in the Bragg Institute this July (2005). Jill also holds an adjunct appointment as Research Professor of Chemistry at the University if Utah where she plans to spend part of each year.

Selected Recent Papers

M. Taraban, H. Zhan, A. E. Whitten, D. B. Langley, K. S. Matthews, L. Swint-Kruse, and J. Trewhella, Ligand-induced conformational changes and conformational dynamics in the solution structure of the lactose repressor protein, J. Mol. Biol., 376(2), 466-481 (2008).

A. E. Whitten, S. Z. Ca, and J. Trewhella, MULCh: modules for the analysis of small-angle neutron contrast variation data from biomolecular assemblies, J. Appl. Crystallogr., 41, 222-226 (2008).

J. Trewhella, Protein kinase A targeting and activation as seen by small-angle solution scattering, European Journal of Cell Biology, 85(7), 655-662 (2006).

J. Trewhella, Structural themes and variations in protein kinase A as seen by small-angle scattering and neutron contrast variation, European Biophysics Journal with Biophysics Letters, 35(7), 585-589 (2006).

S. Ramachandran, J. Trewhella, Y. Tseng, and Y. B. Yu, Coassembling peptide-based biomaterials: Effects of pairing equal and unequal chain length oligopeptides, Chem. Mat., 18(26), 6157-6162 (2006).

T. S. Priddy, B. A. MacDonald, W. T. Heller, O. W. Nadeau, J. Trewhella and G. M. Carlson, Ca²⁺-induced Structural Changes in Phosphorylase Kinase Detected by Small-Angle X-ray Scattering, Protein Science, 14, 1039-1048, (2005).

D. Vigil, D. K. Blumenthal, S. Brown, S. S. Taylor, and J. Trewhella, Differential effects of substrate on type I and type II PKA holoenzyme dissociation, Biochemistry, 43, 5629-5636 (2004).

W. T. Heller, D. Vigil, S. Brown, D. K. Blumenthal, S. S. Taylor, and J. Trewhella, C Subunits binding to the protein kinase a RI alpha dimer induce a large conformational change, Journal of Biological Chemistry, 279, 19084-19090 (2004).

D. Vigil, D. K. Blumenthal, W. T. Heller, S. Brown, J. M. Canaves, S. S. Taylor, and J. Trewhella, Conformational differences among solution structures of the type Ia, IIa and IIb protein kinase A regulatory subunit homodimers: Role of the linker regions, Journal of Molecular Biology, 337, 1183-1194 (2004).

W. T. Heller, J. K. Krueger, and J. Trewhella, Further insights into calmodulin-myosin light chain kinase interaction from solution scattering and shape restoration, Biochemistry, 42, 10579-10588 (2003).

W. T. Heller, N. L. Finley, W. J. Dong, P. Timmins, H. C. Cheung, P. R. Rosevear, and J. Trewhella, Small-angle neutron scattering with contrast variation reveals spatial relationships between the three subunits in the ternary cardiac troponin complex and the effects of troponin I phosphorylation, Biochemistry, 42, 7790-7800 (2003).

M. E. Wall, S. H. Francis, J. D. Corbin, K. Grimes, R. Richie-Jannetta, J. Kotera, B. A. Macdonald, R. R. Gibson and J. Trewhella, Mechanisms Associated with cGMP Binding and Activation of cGMP-Dependent Protein Kinase, Proc. Natl Acad. Sci. USA, 100, 2380-2385, (2003).

S. P. Harris, W. T. Heller, M. L. Greaser, R. L. Moss, and J. Trewhella, Solution structure of heavy meromyosin by small-angle scattering, Journal of Biological Chemistry, 278, 6034-6040 (2003).

C. S. Tung, D. A. Walsh, and J. Trewhella, A structural model of the catalytic subunit-regulatory subunit dimeric complex of the cAMP-dependent protein kinase, Journal of Biological Chemistry, 277, 12423-12431 (2002).

S. C. Gallagher, Z. H. Gao, S. P. Li, B. Dyer, J. Trewhella, and C. B. Klee, There is communication between all four Ca²⁺-bindings sites of calcineurin B, Biochemistry, 40, 12094-12102 (2001).

D. Vigil, S. C. Gallagher, J. Trewhella, and A. E. Garcia, Functional dynamics of the hydrophobic cleft in the N-domain of calmodulin, Biophysical Journal, 80, 2082-2092 (2001).

J. K. Krueger, S. C. Gallagher, G. Zhi, R. Geguchadze, A. Persechini, J. T. Stull, and J. Trewhella, Activation of myosin light chain kinase requires translocation of bound calmodulin, Journal of Biological Chemistry, 276, 4535-4538 (2001).

J. K. Krueger, S. C. Gallagher, C. L. A. Wang, and J. Trewhella, Calmodulin remains extended upon binding to smooth muscle caldesmon: A combined small-angle scattering and Fourier transform infrared spectroscopy study, Biochemistry, 39, 3979-3987 (2000).

C. S. Tung, M. E. Wall, S. C. Gallagher, and J. Trewhella, A model of troponin-I in complex with troponin-C using hybrid experimental data: The inhibitory region is a beta-hairpin, Protein Science, 9, 1312-1326 (2000).